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Environment
A new research published in “Biology Letters”, suggests African desert-dwelling birds prefer their biological sons and alienate their stepsons. “Nepotism has likely played a vital role in the evolution of family life in this species,” said Martha Nelson-Flower, a postdoctoral fellow at the University of British Columbia’s faculty of forestry. The group’s dominant male bird decides which of the subordinate males to tolerate. Nelson-Flower’s research reveals subordinate male birds spend less time in a group if they are unrelated to the dominant male bird. The subordinate males are actually sent out of the group by their stepdads and in some instances by their brothers-in-law. They are then forced to live alone or to join other groups as subordinates. The species is the southern pied blabber, a black and white bird found in Botswana, Namibia, South Africa and Zimbabwe. The chicks are raised by both parents as well as other adult birds and live in groups. The size of the groups range from three to 14 birds. However, this kind of preferential treatment was not seen among the females. “The research is some of the first to show that the sex of both dominant and subordinate birds, and the genetic relationship between them, has a significant impact on their family groups and cooperative breeding behaviour,” said Nelson-Flower. The researchers used data from 11 years of observation.
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Health
A popular group of drugs used to treat type 2 diabetes was shown to have no association with acute pancreatitis but an increased risk of bile duct and gallbladder disease. This was revealed  based on the  first population-based study investigating the possibility of an association with incretin-based drugs. These drugs are proven to be excessively popular for their effectiveness without causing hypoglycaemia, a problem with other classes of diabetes medications. Furthermore, they are shown to have beneficial effects on body weight. “Early signal detection studies suggested that an association might exist. The suspicion was credible because these drugs act directly on the pancreas and there was a concern that they could be responsible for inflammation,” said Dr. Laurent Azoulay, Senior Investigator at the Lady Davis Institute at the Jewish General Hospital and Associate Professor in the Department of Epidemiology, at McGill University. “However, ours was the largest study ever to address the question – involving a cohort of more than 1.5 million patients – and there is no evidence to support that either type of incretin-based drug causes acute pancreatitis.”   Although  they have been prescribed to millions of patients, the safety of the drug remains controversial. Two studies led by Dr. Azoulay, demonstrated that despite an increased risk of bile duct and gallbladder disease, these drugs are not associated with increasing the risk of acute pancreatitis. Both studies are published in the JAMA Internal Medicine. “Notwithstanding the latter finding, the totality of the evidence accumulated to date suggests that incretin-based drugs are effective and generally safe,” Dr. Azoulay concludes. “Nonetheless, it’s important that clinicians and patients alike be well informed about possible adverse effects. As a result of the gallbladder finding, it would be prudent for doctors to warn their patients to seek treatment if they experience symptoms, such as pain in their right side.” The most prevalent adverse effect is gallstones which are treatable but can cause extreme pain. In very severe cases the surgical removal of the gallbladder may be required. The study concluded that nearly 3 more individuals per 1000 will exhibit symptoms as compared with those not taking this medication. “Clinical trials are the gold standard to assess whether medications are effective, but because of their relative small sample sizes and short durations of follow-up, they are not designed to assess the risk of uncommon but clinically important adverse events,” said Dr. Azoulay, “this is where well designed studies conducted in the real-world setting can provide critical information on the safety of medications.”
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